Epigenomic Modifications Mediating Antibody Maturation
نویسندگان
چکیده
منابع مشابه
Epigenomic Modifications Mediating Antibody Maturation
Epigenetic modifications, such as histone modifications, DNA methylation status, and non-coding RNAs (ncRNA), all contribute to antibody maturation during somatic hypermutation (SHM) and class-switch recombination (CSR). Histone modifications alter the chromatin landscape and, together with DNA primary and tertiary structures, they help recruit Activation-Induced Cytidine Deaminase (AID) to the...
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Antibody regions that fit snugly against the antigen, shown in blue, are more abundant in the antibody with higher affinity (bottom). Rockville, MD), and colleagues suggest that protein–protein interactions are optimized by increasing hydrophobic stickiness and improving the fit between proteins. Protein interactions are optimized by evolutionary changes that enhance the binding energy between ...
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ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2018
ISSN: 1664-3224
DOI: 10.3389/fimmu.2018.00355